Generic name: Reduced glutathione for injection
[English name] Reduced Glutathione For Injection
[Efficacy and attending]1. Chemotherapy patients: Cisplatin, cyclophosphamide, doxorubicin, erythrobicin, bleomycin chemotherapy, especially in high-dose chemotherapy; 2. Radiotherapy patients;3. Various hypoxemia: such as acute anemia, adult respiratory distress syndrome, sepsis, etc.4. Liver diseases: including liver damage caused by viral, drug toxicity, alcohol toxicity (including alcoholic fatty liver disease, alcoholic liver fibrosis, alcoholic cirrhosis, acute alcoholic hepatitis) and other chemical toxicity.5. It can also be used in the adjuvant treatment of organophosphorus, amine or nitro compound poisoning.6. Antidrug toxicity (such as tumor chemotherapy drugs, anti-tb drugs, psychoneurotic drugs, antidepressants, acetaminophen, etc.).
[chemical composition] its main component is reduced glutathione, and its structural
[Chemical component] Formula is C10H18O6N3S
1. Reduced glutathione is a tripeptide compound containing sulfhydryl group (SH), which has an activated REDOX system in the human body, activating SH enzyme, detoxification and other important physiological activities.2. This product participates in the tricarboxylic acid cycle and glucose metabolism in the body, promotes the production of high energy in the body, and plays the role of coenzyme. It is the auxiliary group of glyceraldehyde phosphate dehydrogenase, and also the coenzyme of glyoxalase and propionate dehydrogenase.3. This product can activate SH enzyme in the body, promote the metabolism of carbohydrate, fat and protein, and regulate the metabolic process of cell membrane.4. This product is involved in the combination of various exogenous and endogenous toxic substances to produce attenuated substances.
[drug interactions] avoid mixing this product with the following: vitamin K3, vitamin B12, calcium pantothenate, whey acid, antihistamines, long-acting sulfonamides, and tetracycline.
[Adverse reaction] If I occasionally see such allergic symptoms as pale face, decreased blood pressure and abnormal pulse, I should stop taking the medicine. Occasionally see rash and other allergic symptoms, should stop medicine. Occasionally have appetite loss, nausea, vomiting, stomachache and other gastrointestinal symptoms, disappeared after drug withdrawal. The injection was locally mildly painful.
[Contraindications] People who have allergic reactions to this product are not allowed.
[Usage and dosage] 1. Route of administration: 1.1. Intravenous infusion: dissolve it in the water for injection, then add 100ml, 250-500ml normal saline or 5% glucose injection into the intravenous infusion.1.2. Intramuscular injection: dissolve it in water for intramuscular injection.2. Dosage: 2.1. Chemotherapy patients: 1.5g/m2 of this product was dissolved in 100ml normal saline within l5 minutes before chemotherapy drugs were given, and intravenous infusion was given within 15 minutes. In order to prevent urinary system damage when using CTX, it is recommended to give the product intravenously immediately after CTX injection, and the infusion should be finished within 15 minutes. When using cisplatin for chemotherapy, it is recommended that the dosage of this product should not exceed 35mg/mg cisplatin, so as not to affect the effect of chemotherapy.2.2. Adjuvant treatment of liver diseases. For viral hepatitis: 1.2g,qd,iv, 30 days; Severe hepatitis: 1.2 ~ 2.4g,qd,iv, 30 days; Active cirrhosis: 1.2g,qd,iv, 30 days; Fatty liver: 1.8g,qd,iv, 30 days;Alcoholic hepatitis: 1.8g,qd,iv, 14-30 days; Drug-induced hepatitis: 1.2-1.8g,qd,iv, 14-30 days;The infusion time is 1-2 hours.2.3. Used as an adjuvant to radiotherapy and administered after irradiation at a dose of 1.5g/m2, or as directed by the doctor.2.4. For other diseases, such as hypoxemia, 1.5g/m2 of this product can be dissolved in 100ml normal saline by intravenous infusion, and 0.3-0.6g of this product can be injected intramuscular every day for maintenance after the condition improves.3. Course of treatment: liver disease is usually a 30-day course of treatment, and other conditions are determined according to the condition.
[Drug storage]Shading, sealing, storage in a cool place (no more than 20ºC).
1. Use this product in hospital under the supervision of doctors.2. Before injection, it must be completely dissolved with clear and colorless appearance. Keep out of reach of children.4. Stop taking the medicine immediately if there is a rash, pale complexion, drop in blood pressure, abnormal pulse and other symptoms during the course of medication.5. Intramuscular injection should only be used when this route is required and repeated injections at the same site should be avoided.
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