Product Description
Common name:
Artemether injection
Function and function:
This product is suitable for all types of malaria, but it is mainly used for the treatment of chloroquine falciparum malaria and the first aid of the dangerous falciparum malaria.
Usage and dosage:
1. Adult normal dosage, intramuscular injection, first dose 160mg, once a day from the 2nd day, 80mg each time, continuous use for 5 days.
2. Children's usual dosage, intramuscular injection, the first dose according to weight 3.2mg/kg;From the 2nd to the 5th day, each time according to the weight of 1.6mg/kg, once a day.
Adverse reactions:
This product reaction is slight, individual patients have a slight increase in aspartate aminotransferase, alanine aminotransferase, there may be a transient decrease in reticulocyte.
Forbidden:
It's not clear.
Matters needing attention:
If the product has solidification in cold, it can be used after being dissolved at lukewarm temperature.
Ingredients:
The main ingredient of this product is artemether.
Medication for pregnant women and lactating women:
Use with caution in pregnant women.
Pharmacological effects:
pharmacology
Artemether is a derivative of artemisinin, which has a strong and rapid killing effect on the internal stage of plasmodium falciparum, and can quickly control the clinical onset and symptoms.The mechanism of action of artemisinin is still not clear. It mainly interferes with the mitochondrial function of the plasmodium membrane.Artemisinin changes the membrane structure of plasmodium by affecting the ultrastructure of plasmodium red.Due to the effect on the food bubble membrane, the nutrient intake of the plasmodium is blocked, and when the plasmodium loses a large amount of cytoplasm and nutrients, it is not replenished, so it dies quickly.The mechanism of action is through its internal peroxide (dioxygen) bridge, mediated by free iron from hemoglobin decomposition, which produces unstable organic free radicals and/or other electricphilic mediators, which then form a covalent admixture with the protein of the plasmodium, killing the plasmodium.Artemether has six times more antimalarial activity than artemisinin.
Toxicology,
The LD50 of artemether orally in mice was 895 ~ 977mg/kg, and that of artemether oil intramuscular in rats was 597mg/kg.Subacute toxicity test showed that after intramuscular injection of artemether oil at 18mg/kg×14 days, rats had no adverse reactions except a decrease in the number of reticulocytes.This drug has certain embryonic toxicity, which is manifested as embryonic absorption.
Pharmacokinetics:
Absorption is rapid and complete after intramuscular injection.After intramuscular injection of 10mg/kg, the peak blood time was 7 hours, and the peak value could reach about 0.8mg/L, and t1/2 was about 13 hours.It is widely distributed in the body, with the most brain tissue, followed by liver and kidney.Mainly through intestinal excretion, followed by urinary excretion.
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