| Application: | Surgery |
|---|---|
| Suitable for: | Adult |
| State: | Powder |
| Shape: | Powder |
| Type: | Organic Chemicals |
| Pharmaceutical Technology: | Chemical Synthesis |
| Customization: |
|---|
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Audited Supplier [indications]
(1) chemotherapy patients: including cisplatin, cyclophosphamide, adriamycin, red biamycin, bleomycin chemotherapy, especially when the large dose of chemotherapy;
(2) radiotherapy patients;
Various hypoxemia: such as acute anemia, adult respiratory distress syndrome, sepsis, etc.;
(4) liver diseases: including viral, drug toxicity, alcohol toxicity (including alcoholic fatty liver, alcoholic liver fibrosis, alcoholic cirrhosis;Liver damage caused by acute alcoholic hepatitis and other chemical toxicity.
It can also be used in the adjuvant treatment of organophosphorus, amine or nitro compound poisoning.
Antidrug toxicity (such as tumor chemotherapy drugs, anti-tb drugs, psychiatric drugs, antidepressants, acetaminophen, etc.).
usage and dosage
1. Route of administration:
(1) intravenous infusion: after dissolving in the water of injection, add 100ml, 250-500ml normal saline or 5% glucose injection into the intravenous infusion.
(2) intramuscular injection administration: dissolve it in the water after intramuscular injection.
2. Usage:
(1) for chemotherapy patients: 1.5g/m2 of lvtinol was dissolved in 100ml normal saline within 15 minutes before the chemotherapy drugs were given, and intravenous infusion was given within 15 minutes.When using CTX, to prevent urinary system damage, it is recommended to immediately after CTX injection by intravenous infusion of lvtinol, complete infusion within 15 minutes;When using cisplatin for chemotherapy, it is recommended that the dosage of chlorotylenol should not exceed 35mg/mg cisplatin to avoid affecting the effect of chemotherapy.
Liver disease: intramuscular injection or intravenous drip.Mild symptoms: 1~2 times a day, each time 0.3g intramuscular injection or intravenous drip.Severe cases: 1~2 times a day, 0.6g intramuscular injection or intravenous drip.Adjust the dose according to the patient's age and symptoms.Intravenous infusion: sterile lyophilized powder injection was diluted with 250~500ml5% glucose injection or normal saline, and the infusion time was 1~2 hours.Intramuscular injection: dissolve with 4 ml of water.
Other diseases: such as hypoxemia, 1.5g/m2 of lvtinol can be dissolved in 100ml of normal saline intravenous infusion, after the improvement of the condition intramuscular injection of 300~600mg per day to maintain.
3. Course of treatment: the liver disease is generally 30 days for a course of treatment, other conditions are decided according to the condition.
[pharmacological action]
Reduced glutathione (GSH) is a naturally synthesized peptide in human cytoplasm. It is composed of glutamic acid, cysteine and glycine, and contains thiol (-sh).It is an auxiliary group of glyceraldehyde phosphate dehydrogenase, a coenzyme of glyoxalase and propionate dehydrogenase, and participates in the tricarboxylic acid cycle and glucose metabolism in vivo.
It can activate a variety of enzymes [such as sulfhydryl (-sh) enzyme], thereby promoting the metabolism of sugar, fat and protein and affecting the metabolic process of cells.It can be combined with free radicals in the body through sulfhydryl groups, and can be converted into easily metabolized acid substances so as to accelerate the excretion of free radicals, which is conducive to reducing the toxic and side effects of chemotherapy and radiotherapy.
For example, the main mechanism to protect renal tubules from cisplatin damage is the beta-glutathione transpeptidase, which is required for the detoxification of glutathione in renal tubules, while the cancer cells do not have this enzyme, so the normal tissues and organs are protected without affecting the cytotoxic effect of rdinol.
The therapeutic effect on radiation enteritis was obvious.For anemia, poisoning or tissue inflammation caused by systemic or local hypoxemia patients application, can reduce tissue damage, promote repair.GSH can also protect the synthesis of liver, detoxify and inactivate hormones, and promote the metabolism of cholic acid, which is conducive to the absorption of fat and fat-soluble vitamins (A, D, E, K) in the digestive tract.
pharmacokinetics
Mice liver injection reached the peak of blood concentration for about 5 hours, and t1/2 for about 24 hours. It was widely distributed in liver, kidney and muscle.
[contraindication] to glutathione allergy is contraindicated.
[notes]
1. If there is a rash, pale complexion, decreased blood pressure, abnormal pulse and other symptoms in the process of medication, the medication should be stopped immediately.
2. Use the dissolved solution immediately, and do not reuse the remaining solution.
Intramuscular injection should only be used when this route is needed and repeated injection at the same site should be avoided.
[medication for pregnant and lactating women] is not clear
[drug interactions] are not clear
[dosage form] injection
[storage] closed, shading preservation.
[term of validity] 3 years
[manufacturer] chongqing yaoyou pharmaceutical co., LTD
[approval number] national medicine approval word H19991067
Effects and effects of rdinol rdinol is suitable for chemotherapy patients: including the use of cisplatin platinum, cyclophosphamide, adriamycin, red biamycin, bleomycin chemotherapy, especially when large dose of chemotherapy;(2) radiotherapy patients;Various hypoxemia: such as acute anemia, adult respiratory distress syndrome, sepsis, etc.;(4) liver diseases: including viral, drug toxicity, alcohol toxicity (including alcoholic fatty liver, alcoholic liver fibrosis, alcoholic cirrhosis;Liver damage caused by acute alcoholic hepatitis and other chemical toxicity.It can also be used for the adjuvant treatment of organophosphorus, amine or nitro compound poisoning......(see the specification for details)
Common problems with the use of reduced glutathione for injection
Q: what should I note about reduced glutathione for injection?
Answer :1. If there is a rash, pale complexion, decreased blood pressure, abnormal pulse and other symptoms in the process of medication, the medication should be stopped immediately.
2. Use the dissolved solution immediately, and do not reuse the remaining solution.
Intramuscular injection should only be used when this route is needed and repeated injection at the same site should be avoided.
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