Western Medicine Omeprazole Sodium for Injection for I. M/I. V Drugs Inhibiting Gastric Acid Secretion
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- Model NO.: 10 vials
- Usage Mode: For external use
- State: Liquid
- Type: Biological Products
- Origin: China
- Application: Surgery
- Suitable for: Elderly, Adult
- Shape: Powder
- Pharmaceutical Technology: Natural Product Extraction
- HS Code: 3004909099
Each vial contains:
Omeprazole equivalent to 40mg
Omeprazole is a substituted benzimidazole that suppresses gastric acid secretion by specific inhibition of the H'/K' ATP ase enzyme system (proton pump) at the secretory surface of the gastric parietal cell thus blocking the final step of acid production.
It is indicated for disorders associated with hypersecretion of gastric acid such as benign gastric ulcers, duodenal ulcers , gastroesophageal reflux disease and Zollinger-Ellison syndrome.
Hypersensitivity to the components of the formulation.
Warnings and Precautions
Drugs metabolised in the liver:
Omeprazole can prolong the elimination of diazepam , warfarin and phenytoin which are metabolised by oxidation in the liver.
Hence , at the time of concomitant administration , dosage adjustment should be done after careful monitoring of the patient.
Ketoconazole, ampicillin esters and iron salts : Because of its profound and long lasting inhibition of gastric acid secretion, omeprazole may interfere with the absorption of those drugs where gastric PH
is an important determinant of their bioavailability.
There are no adequate or well controlled studies of omeprazole in pregnancy. Hence a decision should be made by taking into account the benefits offered and the potential risk involved.
It is not known whether omeprazole is secreted in breast milk. But becasue of the potential for adverse effects , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into
account the importance of the drug to mother.
Safety and effectiveness has not been established.
Symptomatic response to therapy with omeprazole does not preclude the presence of gastric malignancy.
Nausea , headache , diarrhoea , constipation and flatulence are reported but occur rarely. These events are mild and transient and there has been no consistent relationship with treatment.